Life Sciences Institute and Neuroscience Graduate Program, University of Michigan, Ann Arbor, MI 48109, USA.
Life Sci. 2013 Mar 19;92(8-9):410-4. doi: 10.1016/j.lfs.2012.07.008. Epub 2012 Jul 20.
Drug addiction is a psychiatric disease state, wherein a drug is impulsively and compulsively self-administered despite negative consequences. This repeated administration results in permanent changes to nervous system physiology and architecture. The molecular pathways affected by addictive drugs are complex and inter-dependent on each other. Recently, various new proteins and protein families have been discovered to play a role in drug abuse. Emerging players in this phenomenon include TRP (Transient Receptor Potential) family channels, which are primarily known to function in sensory systems. Several TRP family channels identified in both vertebrates and invertebrates are involved in psychostimulant-induced plasticity, suggesting their involvement in drug dependence. This review summarizes various observations, both from studies in humans and other organisms, which support a role for these channels in the development of drug-related behaviors.
药物成瘾是一种精神疾病状态，在此状态下，尽管存在负面后果，个体仍会冲动且强迫性地自我用药。这种反复用药会导致神经系统的生理和结构发生永久性变化。受成瘾药物影响的分子途径复杂且相互依存。最近，发现了许多新的蛋白质和蛋白质家族在药物滥用中发挥作用。在这种现象中崭露头角的是瞬时受体电位（TRP）家族通道，这些通道主要在感觉系统中发挥作用。在脊椎动物和无脊椎动物中鉴定出的几种 TRP 家族通道都参与了致幻剂诱导的可塑性，这表明它们参与了药物依赖。本综述总结了来自人类和其他生物体的各种观察结果，这些结果支持这些通道在药物相关行为发展中的作用。
