Desai Bimal N, Clapham David E
Department of Neurobiology, Harvard Medical School, Pediatric Cardiology, Children's Hospital of Boston, Howard Hughes Medical Institute, 4000 Jones Bridge Road, Chevy Chase, MD 20815-6789, USA.
Pflugers Arch. 2005 Oct;451(1):11-8. doi: 10.1007/s00424-005-1429-z. Epub 2005 Aug 3.
Transient receptor potential (TRP) channels are a superfamily of functionally versatile cation-permeant ion channels present in almost all mammalian cell types. Although they were initially proposed as store-operated calcium channels, recent progress shows that they exhibit a variety of regulatory and functional themes. Here, we summarize the most salient features of TRP channels, the approaches that are providing meaningful discoveries, and the challenges ahead. We primarily emphasize the understanding gleaned from mouse models engineered to be deficient in various members of TRP superfamily and from the human patients that suffer clinically due to defects in TRP channels.
瞬时受体电位（TRP）通道是一个功能多样的阳离子通透离子通道超家族，几乎存在于所有哺乳动物细胞类型中。尽管它们最初被认为是储存操纵性钙通道，但最近的进展表明它们展现出多种调节和功能模式。在这里，我们总结了TRP通道最显著的特征、带来有意义发现的研究方法以及未来面临的挑战。我们主要强调从工程改造为TRP超家族各成员缺陷型的小鼠模型以及因TRP通道缺陷而患有临床疾病的人类患者身上所获得的认识。
