Centre of Biological Engineering, Department of Chemical Engineering, Loughborough University, Leicestershire, LE11 3TU, United Kingdom.
Adv Drug Deliv Rev. 2013 Apr;65(4):497-514. doi: 10.1016/j.addr.2012.07.007. Epub 2012 Jul 20.
Materials offering the ability to change their characteristics in response to presented stimuli have demonstrated application in the biomedical arena, allowing control over drug delivery, protein adsorption and cell attachment to materials. Many of these smart systems are reversible, giving rise to finer control over material properties and biological interaction, useful for various therapeutic treatment strategies. Many smart materials intended for biological interaction are based around pH or thermo-responsive materials, although the use of magnetic materials, particularly in neural regeneration, has increased over the past decade. This review draws together a background of literature describing the design principles and mechanisms of smart materials. Discussion centres on recent literature regarding pH-, thermo-, magnetic and dual responsive materials, and their current applications for the treatment of neural tissue.
具有响应呈现刺激改变其特性的能力的材料已在生物医学领域得到应用，可控制药物输送、蛋白质吸附和细胞与材料的附着。许多这些智能系统是可逆的，这对材料性能和生物相互作用的控制更加精细，对于各种治疗策略非常有用。许多用于生物相互作用的智能材料基于 pH 或温度响应材料，尽管过去十年中，磁性材料的使用，特别是在神经再生方面，有所增加。这篇综述汇集了描述智能材料的设计原理和机制的文献背景。讨论集中在最近关于 pH、热、磁和双重响应材料的文献及其在神经组织治疗中的当前应用。
