Loiseau P R, Bonnafous M, Caujolle R, Payard M, Loiseau P M, Bories C, Gayral P
Laboratories de Chimie Thérapeutique, Faculté de Pharmacie, Toulouse, France.
Farmaco. 1990 Sep;45(9):953-63.
N-(1,3,4-thiadiazol-2-yl) 1a-1k and N-(1,3,4-oxadiazol-2-yl-) amidines 2a-2g, N-(1,3-thiazol-2-yl) 3a, 3b and N-(1,3-benzothiazol-2-yl-)amidines 4a, 4b were synthesized and tested as anthelminthics, in vitro, against a free nematode (Rhabditis pseudoelongata), against infecting larvae of an intestinal parasite of rats (Nippostrongylus brasiliensis) and against infecting larvae of a filaria (Molinema dessetae).
合成了N-(1,3,4-噻二唑-2-基)的1a - 1k、N-(1,3,4-恶二唑-2-基)脒2a - 2g、N-(1,3-噻唑-2-基)的3a、3b以及N-(1,3-苯并噻唑-2-基)脒4a、4b，并在体外作为驱虫剂进行了测试，以对抗自由线虫（拟长小杆线虫）、大鼠肠道寄生虫（巴西日圆线虫）的感染性幼虫以及丝虫（德氏莫尼线虫）的感染性幼虫。
