Marletta M A, Tayeh M A, Hevel J M
College of Pharmacy, University of Michigan, Ann Arbor 48109-1065.
Biofactors. 1990 Oct;2(4):219-25.
Independent investigations into the biochemical changes and cytostatic properties induced in immunostimulated macrophages and studies involving the identity and mechanism of action of endothelium-derived relaxing factor led to the finding of a new metabolic pathway which converts L-arginine to nitric oxide and citrulline. The pathway has since been reported in a number of additional cell types including cells in the central nervous system (CNS). In the endothelium and CNS nitric oxide is acting as a signaling agent with the evidence supporting activation of the enzyme guanylate cyclase in the target cell. Nitric oxide is toxic and evidence supports a cytostatic/cytotoxic function as the primary action of macrophage-derived nitric oxide.
对免疫刺激巨噬细胞中诱导的生化变化和细胞抑制特性的独立研究，以及涉及内皮源性舒张因子的身份和作用机制的研究，导致发现了一条新的代谢途径，该途径将L-精氨酸转化为一氧化氮和瓜氨酸。此后，在包括中枢神经系统（CNS）细胞在内的许多其他细胞类型中也报道了该途径。在内皮细胞和中枢神经系统中，一氧化氮作为一种信号传导剂，有证据支持靶细胞中鸟苷酸环化酶的激活。一氧化氮具有毒性，有证据支持细胞抑制/细胞毒性功能是巨噬细胞衍生的一氧化氮的主要作用。
