Msellati P, Dupon M, Morlat P, Lacoste D, Pellegrin J L, Dabis F
INSERM U. 330 Département d'Informatique Medicale, Universite de Bordeaux II, France.
AIDS. 1990 Nov;4(11):1105-9. doi: 10.1097/00002030-199011000-00008.
A hospital-based surveillance of HIV infection was implemented in the Bordeaux Regional University Hospital (France). This reporting system, initiated by the Groupe d'Epidemiologie Clinique du SIDA en Aquitaine, identified and followed-up 89 adult patients with transfusion-associated HIV-1 infection (7.2% of all reported cases). Contamination occurred between August 1981 and June 1985 and diagnosis was made between 1985 and 1989. By 30 June 1990, 43 patients (48.3%) had full-blown AIDS, and 28 of them had died. The mean follow-up period was 66 months (s.d. 16 months). The mean incubation period, i.e. The time interval between the contaminating transfusion and the development of full-blown AIDS, was 62 months [median 73 months; 95% confidence interval (CI) 66-82 months]. Five years after contamination, the cumulative probability of reaching the AIDS stage was 34.2% (95% CI 20.3-49.3%), and the probability of survival was 81.7% (95% CI 72.5-90.0%). From this surveillance system we estimate that in south-western France at the end of 1989 the cumulative incidence of transfusion-associated HIV-1 infection was at least 126 cases (45.6 per million inhabitants). Although we anticipate an increase in transfusion-associated AIDS cases over the next 5 years, there have been no reports of contamination after 1 August 1985, when systematic screening of HIV antibodies was implemented in French blood banks. This confirms the efficacy of screening in countries like France where the risk of contamination through blood products is now minimal.
法国波尔多地区大学医院开展了一项基于医院的HIV感染监测。该报告系统由阿基坦地区艾滋病临床流行病学小组发起，共识别并随访了89例成人输血相关HIV-1感染患者（占所有报告病例的7.2%）。感染发生在1981年8月至1985年6月之间，诊断时间为1985年至1989年。截至1990年6月30日，43例患者（48.3%）发展为典型艾滋病，其中28例已经死亡。平均随访期为66个月（标准差16个月）。平均潜伏期，即从感染性输血到发展为典型艾滋病的时间间隔为62个月[中位数73个月；95%置信区间（CI）66 - 82个月]。感染后5年，发展到艾滋病阶段的累积概率为34.2%（95%CI 20.3 - 49.3%），生存概率为81.7%（95%CI 72.5 - 90.0%）。根据这个监测系统，我们估计1989年底法国西南部输血相关HIV-1感染的累积发病率至少为126例（每百万居民45.6例）。尽管我们预计未来5年输血相关艾滋病病例会增加，但自1985年8月1日法国血库实施HIV抗体系统筛查后，没有再报告过感染病例。这证实了在法国这样的国家，筛查是有效的，通过血液制品感染的风险现在已降至最低。
