Center for Biomaterial Development, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht GmbH and Berlin-Brandenburg Centre for Regenerative Therapies, Kantstr 55, 14513 Teltow, Germany.
Macromol Rapid Commun. 2012 Sep 14;33(17):1487-92. doi: 10.1002/marc.201200426. Epub 2012 Jul 23.
Materials for biomedical applications are often chosen for their bulk properties. Other requirements such as a hemocompatible surface shall be fulfilled by suitable chemical functionalization. Here we show, that linear, side-chain methylated oligoglycerols (OGMe) are more stable to oxidation than oligo(ethylene glycol) (OEG). Poly(ether imide) (PEI) membranes functionalized with OGMes perform at least as good as, and partially better than, OEG functionalized PEI membranes in view of protein resistance as well as thrombocyte adhesion and activation. Therefore, OGMes are highly potent surface functionalizing molecules for improving the hemocompatibility of polymers.
用于生物医学应用的材料通常因其体相性质而被选择。其他要求，如血液相容性表面，可通过合适的化学官能化来满足。在这里，我们表明，线性、侧链甲基化的低聚甘油（OGMe）比聚（乙二醇）（OEG）更稳定，不易被氧化。用 OGMe 官能化的聚醚酰亚胺（PEI）膜在抗蛋白污染以及血小板黏附和激活方面的性能至少与 OEG 官能化的 PEI 膜一样好，在某些情况下甚至更好。因此，OGMe 是一种非常有效的表面官能化分子，可提高聚合物的血液相容性。
