Shugyo A, Mori N, Matsunaga T
Department of Otolaryngology, Kagawa Medical School, Japan.
Eur Arch Otorhinolaryngol. 1990;248(2):79-81. doi: 10.1007/BF00240224.
The endocochlear potential (EP) and the K+ activity in the scala media of the guinea pig were recorded by means of K(+)-sensitive, double-barrelled microelectrodes in the second turn of the cochlea. EP and K+ change were recorded during the perilymphatic perfusion of furosemide and ouabain. Furosemide produced less of a decrease than ouabain in the K+ activity relative to the EP decrease. These results suggest that furosemide reduces the EP via different mechanisms from the inhibition of the K+ secretion potential.
采用钾离子敏感双管微电极，在豚鼠耳蜗第二圈记录内淋巴电位（EP）和中阶的钾离子活性。在进行呋塞米和哇巴因外淋巴灌注期间，记录EP和钾离子变化。相对于EP降低，呋塞米引起的钾离子活性降低幅度小于哇巴因。这些结果表明，呋塞米通过不同于抑制钾离子分泌电位的机制降低EP。
