Plank Christian, Vlaskou Dialechti, Schillinger Ulrike, Mykhaylyk Olga
Institute of Experimental Oncology and Therapy Research, Klinikum rechts der Isar, Technical University Munich, Germany.
Ther Deliv. 2011 Jun;2(6):717-26. doi: 10.4155/tde.11.37.
Nucleic acid delivery to cells to make them produce a desired protein or to shut down the expression of endogenous genes opens unique possibilities for research and therapy. During the last decade, to realize the potential of this approach, nanomagnetic methods for delivering and targeting nucleic acids have been developed, methods which are often referred to as Magnetofection. Our research group at the Institute of Experimental Oncology and Therapy Research, located at the University Hospital Klinikum rechts der Isar in the center of Munich, Germany, develops new magnetic nanomaterials and, their formulations with gene-delivery vectors and technologies to allow localized and efficient gene delivery in vitro and in vivo for a variety of research, diagnostic and therapeutic applications.
将核酸导入细胞以使其产生所需蛋白质或关闭内源性基因的表达，为研究和治疗开辟了独特的可能性。在过去十年中，为了实现这种方法的潜力，已经开发出用于递送和靶向核酸的纳米磁性方法，这些方法通常被称为磁转染。我们位于德国慕尼黑市中心伊萨尔河右岸大学医院的实验肿瘤学和治疗研究所以及治疗研究的研究小组，开发了新的磁性纳米材料及其与基因递送载体和技术的配方，以便在体外和体内进行局部高效的基因递送，用于各种研究、诊断和治疗应用。
