Pain J A, Cahill C J
King's College Hospital, London.
Br J Clin Pract. 1990 Nov;44(11):454-6.
In order to establish the current treatment of cyclical mastalgia, a postal questionnaire was sent to 276 consultant general surgeons (over 25% of the UK total), randomly selected from the 12 UK regional health authorities. Surgeons were questioned about their choices of treatment for cyclical mastalgia, after initial resassurance, and for persistent pain. Two hundred and forty-five (89%) responded, out of whom 219 saw patients with breast disease. Twenty-three (11%) of these surgeons were identified as having a major interest in breast disease. Danazol, used by 75% of surgeons, was the drug most commonly prescribed. Initial treatments by non-specialist surgeons included danazol (31%), analgesia (19%) and diuretics (17%), and by breast surgeons evening primrose oil (30%), tamoxifen (13%) and vitamin B6 (13%). For persistent pain 46% of non-specialist surgeons prescribed danazol and 18% surgery, whereas 65% of breast surgeons prescribed danazol and 30% bromocriptine. A wide variety of therapies are used, but danazol is the most common. For persistent unresponsive pain, local excision biopsy surgery is frequently considered by non-specialist surgeons. Breast specialist tend initially to use other methods that are associated with fewer side-effects and reserve other treatments such as danazol and bromocriptine for persistent cases.
为了确定目前周期性乳房疼痛的治疗方法,我们向从英国12个地区卫生当局随机抽取的276名普通外科顾问医生(占英国总数的25%以上)发送了一份邮政调查问卷。外科医生被问及他们在初次安抚后对周期性乳房疼痛以及持续性疼痛的治疗选择。245人(89%)做出了回应,其中219人诊治患有乳腺疾病的患者。这些外科医生中有23人(11%)被确定对乳腺疾病有主要兴趣。75%的外科医生使用达那唑,这是最常用的药物。非专科外科医生的初始治疗方法包括达那唑(31%)、镇痛(19%)和利尿剂(17%),而乳腺外科医生的初始治疗方法包括月见草油(30%)、他莫昔芬(13%)和维生素B6(13%)。对于持续性疼痛,46%的非专科外科医生开了达那唑,18%选择了手术,而65%的乳腺外科医生开了达那唑,30%开了溴隐亭。使用了各种各样的治疗方法,但达那唑是最常用的。对于持续无反应的疼痛,非专科外科医生经常考虑进行局部切除活检手术。乳腺专科医生最初倾向于使用其他副作用较少的方法,并将达那唑和溴隐亭等其他治疗方法留用于持续性病例。