Gariani Karim, de Seigneux Sophie, Courbebaisse Marie, Lévy Marc, Moll Solange, Martin Pierre-Yves
Department of Internal Medicine, Divison of General Internal Medicine, 4 rue Gabrielle-Perret-Gentil, 1211 Genève 4, Geneva, Switzerland.
J Med Case Rep. 2012 Jul 23;6:215. doi: 10.1186/1752-1947-6-215.
Oxalate nephropathy has various etiologies and remains a rare cause of renal failure. To the best of our knowledge, we report the first case of oxalate nephropathy following octreotide therapy.
We report the case of a 78-year-old Caucasian man taking chronic octreotide treatment for acromegaly who presented with acute oxalate nephropathy after antibiotic therapy. The diagnosis was confirmed by urinary analysis and a kidney biopsy. The recovery of renal function was favorable after hydration and withdrawal of octreotide therapy.
Oxalate nephropathy should be suspected in patients at risk who present with acute kidney injury after prolonged antibiotic treatment. This diagnosis should be distinguished from immuno-allergic interstitial nephritis and requires specific care. The evolution of this condition may be favorable if the pathology is identified correctly. Octreotide therapy should be considered a risk factor for enteric oxaluria.
草酸盐肾病病因多样，仍然是肾衰竭的罕见原因。据我们所知，我们报告了首例奥曲肽治疗后发生的草酸盐肾病病例。
我们报告了一名78岁白人男性病例，该患者因肢端肥大症接受长期奥曲肽治疗，在接受抗生素治疗后出现急性草酸盐肾病。通过尿液分析和肾脏活检确诊。水化治疗并停用奥曲肽治疗后，肾功能恢复良好。
对于长期抗生素治疗后出现急性肾损伤的高危患者，应怀疑草酸盐肾病。该诊断应与免疫过敏性间质性肾炎相鉴别，且需要特殊治疗。如果病理诊断正确，该病的病情发展可能较好。奥曲肽治疗应被视为肠道草酸盐尿症的一个危险因素。
