Institut des Neurosciences Cellulaires et Intégratives, Centre National de la Recherche Scientifique, Strasbourg, France.
Trends Neurosci. 2012 Nov;35(11):681-90. doi: 10.1016/j.tins.2012.06.007. Epub 2012 Jul 21.
The tail of the ventral tegmental area (tVTA), also named the rostromedial tegmental nucleus (RMTg), is a recently defined midbrain structure considered to exert a major inhibitory drive on dopamine systems. In view of its connectivity, tVTA is well placed to convey salient positive and negative signals to dopamine cells and participate in adaptative behavioral responses. This structure could act as a hub converging and integrating widespread multimodal signals toward dopamine systems. The tVTA participates in prediction error, motor control, and responses to aversive stimuli and drugs of abuse. In light of the crucial role of the tVTA in the opiate control of dopamine activity, a neuroanatomical update of the disinhibition model of morphine action is proposed.
腹侧被盖区（VTA）的尾部，也称为延髓腹侧被盖核（RMTg），是最近定义的中脑结构，被认为对多巴胺系统施加主要的抑制驱动。鉴于其连接性，tVTA 很好地将显著的正信号和负信号传递给多巴胺细胞，并参与适应性行为反应。该结构可以作为一个枢纽，将广泛的多模态信号汇聚和整合到多巴胺系统中。tVTA 参与预测误差、运动控制以及对厌恶刺激和滥用药物的反应。鉴于 tVTA 在阿片类药物控制多巴胺活动中的关键作用，提出了吗啡作用的去抑制模型的神经解剖学更新。
