School of Architecture, Southwest JiaoTong University, Chengdu, China.
Psychological Research and Counseling Center, Southwest Jiaotong Univerisity, Chengdu, China.
PLoS One. 2023 Sep 28;18(9):e0286569. doi: 10.1371/journal.pone.0286569. eCollection 2023.
To provide an overview of the evidence on the effect of light therapy on sleep disturbance and depression, identify the light-active neural and hormonal correlates of the effect of light therapy on sleep disturbance comorbid depression (SDCD), and construct the mechanism by which light therapy alleviates SDCD.
Articles published between 1981 and 2021 in English were accessed using Science Direct, Elsevier, and Google Scholar following a three-step searching process via evolved keywords. The evidence level, reliability, and credibility of the literature were evaluated using the evidence pyramid method, which considers the article type, impact factor, and journal citation report (JCR) partition.
A total of 372 articles were collected, of which 129 articles fit the inclusion criteria and 44% were at the top of the evidence pyramid hierarchy; 50% were in the first quarter of the JCR partitions. 114 articles provided specific neural and hormonal evidence of light therapy and were further divided into three groups: 37% were related to circadian regulation circuits, 27% were related to emotional regulation circuits, and 36% were related to hormones.
First, neural and hormonal light-active pathways for alleviating sleep disturbance or depression were identified, based on which the neural correlates of SDCD were located. Second, the light responses and interactions of hormones were reviewed and summarized, which also provided a way to alleviate SDCD. Finally, the light-active LHb and SCN exert extensive regulation impacts on the circadian and emotional circuits and hormones, forming a dual-core system for alleviating SDCD.
综述光照疗法对睡眠障碍和抑郁影响的证据，确定光照疗法对睡眠障碍共病抑郁（SDCD）影响的光活性神经和激素相关性，并构建光照疗法缓解 SDCD 的机制。
通过进化关键词的三步搜索过程，使用 Science Direct、Elsevier 和 Google Scholar 检索 1981 年至 2021 年间发表的英文文章。使用证据金字塔方法评估文献的证据水平、可靠性和可信度，该方法考虑文章类型、影响因子和期刊引文报告（JCR）分区。
共收集了 372 篇文章，其中 129 篇符合纳入标准，44%处于证据金字塔层次的顶端；50%位于 JCR 分区的第一季度。114 篇文章提供了光照疗法的特定神经和激素证据，并进一步分为三组：37%与昼夜节律调节回路有关，27%与情绪调节回路有关，36%与激素有关。
首先，确定了缓解睡眠障碍或抑郁的光活性神经和激素途径，据此定位了 SDCD 的神经相关性。其次，回顾和总结了激素的光反应和相互作用，这也为缓解 SDCD 提供了一种方法。最后，光活性 LHb 和 SCN 对昼夜节律和情绪回路以及激素发挥广泛的调节作用，形成缓解 SDCD 的双核心系统。
