Division of Pediatric Gastroenterology and Hepatology, Seattle Children's Hospital, WA 98115, USA.
Clin Liver Dis. 2012 Aug;16(3):587-98. doi: 10.1016/j.cld.2012.05.004. Epub 2012 Jun 23.
Nonalcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in children, and can present in toddlerhood. There is a differential distribution of NAFLD in children based on race and gender. The gold standard for diagnosis and classification of pediatric NAFLD is liver biopsy although ongoing studies aim to identify and define noninvasive investigations for pediatric NAFLD. Treatments that have been shown to be successful in adult NAFLD, such as insulin sensitizers and Vitamin E, have not been proven to be as definitively successful in children with NAFLD.
非酒精性脂肪性肝病（NAFLD）是儿童慢性肝病的主要原因，可在幼儿期发病。儿童的 NAFLD 分布因种族和性别而异。肝活检虽然目前的研究旨在确定和定义非侵入性的儿科 NAFLD 调查，但它仍然是诊断和分类儿科 NAFLD 的金标准。在成人 NAFLD 中已被证明有效的治疗方法，如胰岛素增敏剂和维生素 E，在儿童 NAFLD 中尚未被证明同样有效。
