Zhao Kanglu, Ju Hongzhen, Wang Haili
Department of Infectious Disease, The Fourth Affiliated Hospital Zhejiang University, School of Medicine, Yiwu.
Department of Infectious Disease, The First Affiliated Hospital Zhejiang University, School of Medicine, Hangzhou.
Medicine (Baltimore). 2019 Apr;98(16):e14939. doi: 10.1097/MD.0000000000014939.
To investigate metabolic differences between simple obese children and those comorbid with fatty liver disease.Obese children hospitalized in our center from 2014 to 2016 were included and divided into simple obese group and obese with fatty liver group by ultrasound-based diagnosis of fatty liver. Epidemiology data and serum biochemical studies were recorded. Body Mass Index (BMI) and homeostasis model insulin resistance index (HOMA-IR) were calculated accordingly.A total of 186 obese children were enrolled in this study, including 93 cases of obese children and 93 obese patients' comorbid with fatty liver. The proportion of male, age, waist circumference (WC), BMI, fasting blood-glucose (FBG), glycosylated hemoglobin A1c (HbA1c), fasting insulin (FINS), and HOMA-IR were significantly higher in obese patients with fatty liver (P <.05). Age and BMI were found to be independent risk factors for fatty liver disease (OR >1, P <.05).Among obese children, male and elder patients and individuals with higher uric acid are more susceptible to fatty liver.
探讨单纯肥胖儿童与合并脂肪肝疾病儿童之间的代谢差异。纳入2014年至2016年在本中心住院的肥胖儿童，根据基于超声诊断的脂肪肝将其分为单纯肥胖组和肥胖合并脂肪肝组。记录流行病学数据和血清生化研究结果。相应计算体重指数（BMI）和稳态模型胰岛素抵抗指数（HOMA-IR）。本研究共纳入186例肥胖儿童，其中肥胖儿童93例，肥胖合并脂肪肝患者93例。肥胖合并脂肪肝患者的男性比例、年龄、腰围（WC）、BMI、空腹血糖（FBG）、糖化血红蛋白A1c（HbA1c）、空腹胰岛素（FINS）和HOMA-IR显著更高（P<0.05）。年龄和BMI被发现是脂肪肝疾病的独立危险因素（OR>1，P<0.05）。在肥胖儿童中，男性、年长患者和尿酸较高者更容易患脂肪肝。
