J Biol Regul Homeost Agents. 2012 Apr-Jun;26(2):181-92.
Data on the immunohistochemical expression and localization of the five somatostatin receptors (SSTRs) have been obtained by our group in separate studies concerning the many faces of prostate cancer (PCa), its precursor high grade prostatic intraepithelial neoplasia (HGPIN) and normal epithelium (Nep). This publication highlights the key findings, with special reference to: normal prostate epithelium; untreated HGPIN and PCa, both clinically and incidentally detected; PCa with NE differentiation; HGPIN and PCa following complete androgen ablation (CAA); and hormone refractory (HR) PCa. Taken together, the data obtained in these investigations demonstrate that SSTR profiling in individual patients with HGPIN and the multifaceted PCa is feasible and is of relevance to better tailor the somatostatin analogue-based treatment.
我们的研究小组已经获得了关于前列腺癌（PCa）、其前体高级别前列腺上皮内瘤变（HGPIN）和正常上皮（Nep）的许多方面的五种类生长抑素受体（SSTRs）的免疫组化表达和定位数据。本出版物重点介绍了关键发现，并特别提到：正常前列腺上皮；未经治疗的 HGPIN 和 PCa，无论是临床还是偶然发现的；具有 NE 分化的 PCa；完全雄激素剥夺（CAA）后的 HGPIN 和 PCa；以及激素难治性（HR）PCa。总之，这些研究中获得的数据表明，对个别 HGPIN 和多方面 PCa 患者进行 SSTR 分析是可行的，并且与更好地定制基于生长抑素类似物的治疗相关。
