Bodnar R J, Paul D, Rosenblum M, Liu L, Pasternak G W
Cotzias Laboratory of Neuro-Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Brain Res. 1990 Oct 8;529(1-2):324-8. doi: 10.1016/0006-8993(90)90845-3.
Rats demonstrating analgesia following microinjection of morphine into the periaqueductal gray (PAG) or locus coeruleus (LC) were injected with either pertussis toxin, cholera toxin or saline into the same brain region. Both pertussis and cholera toxin blocked the analgesic effect of morphine at both injection sites for up to 7 days after toxin treatment. These results indicate that morphine analgesia is a complex response involving systems dependent upon Gs as well as Gi or Go proteins.
向中脑导水管周围灰质（PAG）或蓝斑（LC）微量注射吗啡后表现出镇痛作用的大鼠，在相同脑区注射百日咳毒素、霍乱毒素或生理盐水。在毒素处理后的长达7天内，百日咳毒素和霍乱毒素均在两个注射部位阻断了吗啡的镇痛作用。这些结果表明，吗啡镇痛是一种复杂的反应，涉及依赖Gs以及Gi或Go蛋白的系统。
