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粒细胞巨噬细胞集落刺激因子对体外培养的中枢胆碱能神经元的营养作用。

Trophic effect of granulocyte-macrophage colony-stimulating factor on central cholinergic neurons in vitro.

作者信息

Kamegai M, Konishi Y, Tabira T

机构信息

Division of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo, Japan.

出版信息

Brain Res. 1990 Nov 5;532(1-2):323-5. doi: 10.1016/0006-8993(90)91775-c.

DOI:10.1016/0006-8993(90)91775-c
PMID:2282525
Abstract

Granulocyte-macrophage colony-stimulating factor (GM-CSF) elevated choline acetyltransferase (ChAT) activities of mouse septal neurons as well as of cholinergic hybridoma line cells SN6.10.2.2 in vitro. It augmented ChAT activities and neurite extension of interleukin 3-activated cholinergic neurons. Thus, GM-CSF should be added as a trophic factor for central cholinergic neurons.

摘要

粒细胞-巨噬细胞集落刺激因子（GM-CSF）在体外可提高小鼠隔区神经元以及胆碱能杂交瘤细胞系SN6.10.2.2的胆碱乙酰转移酶（ChAT）活性。它增强了白细胞介素3激活的胆碱能神经元的ChAT活性和神经突延伸。因此，GM-CSF应作为中枢胆碱能神经元的一种营养因子添加。

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