Kamegai M, Niijima K, Kunishita T, Nishizawa M, Ogawa M, Araki M, Ueki A, Konishi Y, Tabira T
Division of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo, Japan.
Neuron. 1990 Mar;4(3):429-36. doi: 10.1016/0896-6273(90)90055-k.
We have found that interleukin 3 (IL-3), a growth factor for hematopoietic cells, is a novel trophic factor for mouse and rat central cholinergic neurons. It enhanced neurite outgrowth and elevated choline acetyltransferase activity. The effect seems to be specific for cholinergic neurons, since somatostatin release and glutamic acid decarboxylase and 2',3'-cyclic nucleotide 3'-phosphodiesterase activities were not significantly influenced by IL-3. In vivo, IL-3 was infused into the lateral ventricles of rats after unilateral axotomy of the septohippocampal pathways. Two weeks later, the IL-3-treated animals showed significant numbers of acetylcholinesterase-positive neurons remaining in the septal region.
我们发现，白细胞介素3（IL-3）作为造血细胞的生长因子，是小鼠和大鼠中枢胆碱能神经元的一种新型营养因子。它可促进神经突生长并提高胆碱乙酰转移酶活性。这种作用似乎对胆碱能神经元具有特异性，因为生长抑素释放以及谷氨酸脱羧酶和2',3'-环核苷酸3'-磷酸二酯酶活性并未受到IL-3的显著影响。在体内实验中，在大鼠海马隔区通路单侧轴突切断后，将IL-3注入大鼠侧脑室。两周后，接受IL-3治疗的动物在隔区仍有大量乙酰胆碱酯酶阳性神经元。
