Department of Cardiology, Fourth People's Hospital of Wuxi and Affiliated Hospital of Jiangnan University, Wuxi 216042, PR China.
Mol Med Rep. 2012 Oct;6(4):894-6. doi: 10.3892/mmr.2012.995. Epub 2012 Jul 18.
Interleukin-10 (IL-10) is a multifunctional anti-inflammatory cytokine involved in various physiological and pathophysiological processes including cardiovascular disease. It has been reported that 50-75% of the variation in IL-10 production is genetically controlled. In the present study, the IL-10 -1082A/G (rs1800896) polymorphism was detected in 174 coronary artery disease (CAD) patients confirmed by selective coronary angiography and 176 age and gender-matched controls from the Jiangsu area (East China). The majority of the subjects (93.14%) carried the AA wild-type genotype, whereas only 0.29% carried the GG genotype. Our results suggest that IL-10 -1082A/G is rare and unlikely to be a significant contributory to disease susceptibility in the Han Chinese population.
白细胞介素-10（IL-10）是一种多功能抗炎细胞因子，参与多种生理和病理生理过程，包括心血管疾病。据报道，IL-10 产生的 50-75%的变异是由遗传控制的。在本研究中，通过选择性冠状动脉造影证实了 174 例冠状动脉疾病（CAD）患者和来自华东地区（江苏）的 176 名年龄和性别匹配的对照者中存在白细胞介素-10 -1082A/G（rs1800896）多态性。大多数受试者（93.14%）携带 AA 野生型基因型，而仅 0.29%携带 GG 基因型。我们的结果表明，IL-10 -1082A/G 较为罕见，不太可能是汉族人群疾病易感性的重要因素。
