Department of Cardiology, Ningxia People's Hospital, 148 West Huaiyuan Road, Yinchuan 750021, People's Republic of China.
Cytokine. 2011 Jul;55(1):1-3. doi: 10.1016/j.cyto.2011.03.006. Epub 2011 Apr 6.
Interleukin-6 (IL-6) is a cytokine involved in different physiologic and pathophysiologic processes including essential hypertension (EH). Associations of the IL-6 promoter region polymorphisms with circulating level of IL-6 have been reported in various studies. We detected the IL-6-597G/A polymorphism in 246 EH patients and 194 healthy controls from Jiangsu area (south of China). Individuals all carried the GG wild genotype, no GA or AA genotypes were found. Our results suggest that IL-6-597G/A polymorphism is extremely rare and unlikely to be contributing significantly to disease susceptibility in southern Han Chinese.
白细胞介素-6（IL-6）是一种细胞因子，参与多种生理和病理生理过程，包括原发性高血压（EH）。在不同的研究中已经报道了白细胞介素-6启动子区域多态性与循环中白细胞介素-6水平的关联。我们在 246 名来自江苏地区（中国南方）的 EH 患者和 194 名健康对照中检测了白细胞介素-6-597G/A 多态性。所有个体均携带 GG 野生基因型，未发现 GA 或 AA 基因型。我们的结果表明，白细胞介素-6-597G/A 多态性非常罕见，不太可能显著导致南方汉族人群易患疾病。
