Mestres Olga, Poca María A, Solana Elizabeth, Radoi Andreea, Quintana Manuel, Force Enriqueta, Sahuquillo Juan
Unidad de Investigación de Neurotraumatología y Neurocirugía, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Escuela Universitaria de Enfermería, Barcelona, España.
Rev Neurol. 2012 Aug 1;55(3):148-56.
The Chiari type I malformation (CM-I) is a low prevalence disorder whose manifestations vary highly, depending on the associated malformative complex. The people with a CM-I can suffer anxiety, depression symptoms and an un-defined loss of quality of life. The main purpose of this study is to establish the impact of CM-I on quality of life, as well as the presence of anxiety and depression in these patients.
Prospective study of a cohort of 67 patients suffering from CM-I who undergo an evaluation by means of the SIP scale (Sickness Impact Profile), STAI (State-Trait Anxiety Inventory) and BDI (Beck's Depression Inventory) of their quality of life and of the presence of anxiety and depressive symptoms respectively. For every patient the degree of cerebellar tonsillar ectopia and the presence of syringomyelia and/or hydrocephalus were registered.
The impact of the CM-I on the quality of life was none for 6 patients (9%), mild for 36 (53.7%), moderate for 17 (25.4%) and severe for 8 (11.9%). The most affected area of activity was work. A total of 86.6% of the patients presented a moderate or high anxiety level. In 25.4% of the patients moderate or severe depressive symptoms were also acknowledged.
The great majority of patients with a CM-I consider that their disorder implies a loss of their quality of life which, in many cases, is associated with high anxiety and depressive symptoms.
Chiari I型畸形（CM-I）是一种患病率较低的疾病，其表现高度多样，取决于相关的畸形复合体。患有CM-I的人可能会出现焦虑、抑郁症状以及生活质量的不明下降。本研究的主要目的是确定CM-I对生活质量的影响，以及这些患者中焦虑和抑郁的存在情况。
对67例患有CM-I的患者进行前瞻性队列研究，分别通过疾病影响量表（SIP）、状态-特质焦虑量表（STAI）和贝克抑郁量表（BDI）对他们的生活质量以及焦虑和抑郁症状的存在情况进行评估。记录每位患者小脑扁桃体下疝的程度以及脊髓空洞症和/或脑积水的存在情况。
CM-I对生活质量无影响的患者有6例（9%），轻度影响的有36例（53.7%），中度影响的有17例（25.4%），重度影响的有8例（11.9%）。受影响最严重的活动领域是工作。共有86.6%的患者表现出中度或高度焦虑水平。25.4%的患者也存在中度或重度抑郁症状。
绝大多数CM-I患者认为他们的疾病意味着生活质量下降，在许多情况下，这与高度焦虑和抑郁症状有关。
