Department of Clinical Allergology, Pomeranian Medical University, Szczecin, Poland.
Adv Exp Med Biol. 2013;755:169-77. doi: 10.1007/978-94-007-4546-9_22.
β2-adrenergic receptors re abundantly expressed in airways, which explains the role of β2 agonists, the strongest bronchodilators, in treatment of bronchial constriction. There may be a relation between β2ADR gene polymorphism and the response to treatment with β2 agonists. In the present study we attempted to study these relationship in vivo, estimating spirometric values before and after the use of salbutamol in reference to variant of β2ADR gene polymorphisms. The study involved 148 healthy male volunteers. After the examination of the gene polymorphism of the β2-adrenergic receptor (β2-ADR) at nucleotide positions 46 and 79 (g.46 and g.79) we performed spirometry testing in all subjects. The pulmonary function was checked twice a day; before and 15 min after the administration of salbutamol. All subjects had normal basic values of spirometry. The use of salbutamol significantly increased spirometric values in all groups determined by β2ADR gene polymorphisms. Analysis of the spirometric values in individual groups showed a significant increase only in peak expiratory flow (g.46AA and g.79CC). The results of this study give an insight into a possibly important mechanism of the response to treatment with β2-agonists.
β2-肾上腺素能受体在气道中大量表达，这解释了β2 激动剂（最强的支气管扩张剂）在治疗支气管收缩中的作用。β2ADR 基因多态性与β2 激动剂治疗反应之间可能存在关系。本研究试图在体内研究这些关系，即在参考β2ADR 基因多态性变异的情况下，估计使用沙丁胺醇前后的肺活量计值。该研究涉及 148 名健康男性志愿者。在检查了β2-肾上腺素能受体（β2-ADR）在核苷酸位置 46 和 79（g.46 和 g.79）的基因多态性后，我们对所有受试者进行了肺活量计测试。肺功能每天检查两次；沙丁胺醇给药前和给药后 15 分钟。所有受试者的基础肺活量计值均正常。β2ADR 基因多态性确定的所有组中，沙丁胺醇的使用均显著增加了肺活量计值。对各小组肺活量计值的分析表明，仅在呼气峰流量（g.46AA 和 g.79CC）中显著增加。本研究的结果深入了解了对β2-激动剂治疗反应的一个可能重要机制。
