Department of Clinical Allergology, Pomeranian Medical University, Szczecin, Poland.
Eur J Med Res. 2010 Nov 4;15 Suppl 2(Suppl 2):135-40. doi: 10.1186/2047-783x-15-s2-135.
The vagus nerve plays a special role in the control of respiratory system activity which represents the parasympathetic part of the autonomic nervous system. A small bronchial innervation by the sympathetic system also is observed, and there is a significant expression of adrenergic receptors, in particular β⊂2 receptors, in the airways. The development of genetics and molecular biology allows for a detailed study which can clarify the essential elements in the pathogenesis of many types of lung disease, as well as the physiological phenomena - bronchial smooth muscle tone and their contractile mechanism.
The study involved 148 healthy male volunteers aged 20-26. In all subjects, gene polymorphism at nucleotide position 46 and 79 of β⊂2-adrenergic receptor (β⊂2-ADR) was assessed. According to the gene polymorphism data, we divided the whole examined population of males into 6 groups for further studies. Moreover, in all the subjects, we performed spirometry testing to verify their pulmonary functions.
The basic values of spirometry tests in all subjects were in the range of normal values. The frequency of different genotypes in the gene polymorphism of the β⊂2-adrenergic receptor at nucleotide positions 46 and 79 were typical for the Caucasian population. Analysis of the output values of spirometry, conducted in the particular groups based on their genotype, showed significant inter-group differences in the selected spirometry tests.
Our results may be useful in explaining the differences in the measured values of spirometric indices in healthy subjects in relation to the polymorphism of β⊂2-ADR, and may also contribute to the verification of standards for spirometric indices for this selected group of young males in the Polish population.
迷走神经在呼吸系统活动的控制中发挥特殊作用，它代表自主神经系统的副交感部分。也观察到交感神经系统对支气管有小的神经支配，并且气道中存在大量肾上腺素能受体，特别是β₂受体的表达。遗传学和分子生物学的发展使得能够进行详细的研究，从而阐明许多类型的肺部疾病的发病机制以及生理现象（支气管平滑肌张力及其收缩机制）中的基本要素。
本研究纳入了 148 名 20-26 岁的健康男性志愿者。在所有受试者中，均评估了β₂-肾上腺素能受体（β₂-ADR）核苷酸位置 46 和 79 的基因多态性。根据基因多态性数据，我们将整个男性研究人群分为 6 组进行进一步研究。此外，对所有受试者进行了肺功能测试，以验证其肺功能。
所有受试者的肺功能测试基本值均在正常值范围内。β₂-肾上腺素能受体核苷酸位置 46 和 79 基因多态性的不同基因型在所有受试者中的频率均为典型的白种人群。根据基因型在特定组中进行的肺功能测试输出值分析显示，在所选的肺功能测试中，组间存在显著差异。
我们的研究结果可能有助于解释健康受试者的肺功能测试指标的测量值与β₂-ADR 多态性之间的差异，并且可能有助于验证波兰人群中该特定年轻男性群体的肺功能测试指标标准。
