Dabouis G, Nomballais M F, Maury B, Peltier P, Morineau J F, Corroller J
Poumon Coeur. 1979;35(4):211-6.
Endobronchial localizations of the granular cell tumours or Abrikossoff's tumour are very rare (6%) but their association with malignant tumours is exceptional and perhaps fortuitous. The clinical manifestations are generally the consequence of bronchial erosion and blocking. Bronchial endoscopy is the essential examination which allows the tumour to be seen and a biopsy to be made. Pathological examination confirms the diagnosis. The typicall cell of granular cell tumour is a large, polygonal one with finely granular eosinophilic cytoplasm and a small dark vesicular nucleus. Such cells are arranged in syncytial masses containing long, spindleshape cells with elongated nuclei. If the optical and elctron microscope description is well known, the histogenesis of the disease is still in dispute; the neurogenic origin seems to be the best one, but at present there is not enough evidence to make this assumption a certainty. Surgical exeresis is the only therapy to bring about a cure, but clinical supervision is necessary because of a possible relapse.
颗粒细胞瘤或阿布里科索夫瘤的支气管内定位非常罕见(6%),但其与恶性肿瘤的关联极为罕见,可能是偶然的。临床表现通常是支气管侵蚀和阻塞的结果。支气管镜检查是必不可少的检查,可观察到肿瘤并进行活检。病理检查可确诊。颗粒细胞瘤的典型细胞是大的多角形细胞,胞质嗜酸性且有细颗粒,核小而深染呈泡状。这些细胞排列成含有长梭形细胞且细胞核细长的合体细胞团块。虽然光学显微镜和电子显微镜下的描述为人熟知,但该疾病的组织发生仍存在争议;神经源性起源似乎是最合理的,但目前尚无足够证据确定这一假设。手术切除是实现治愈的唯一疗法,但由于可能复发,临床监测是必要的。