伊朗伊斯法罕教养中心青少年丙型肝炎病毒血清流行率及危险因素
Seroprevalence and Risk Factors of Hepatitis C Virus among Juveniles in Correctional Center in Isfahan, Iran.
作者信息
Nokhodian Zary, Ataei Behrooz, Kassaian Nazila, Yaran Majid, Hassannejad Razieh, Adibi Peyman
机构信息
Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
Int J Prev Med. 2012 Mar;3(Suppl 1):S113-7.
OBJECTIVES
Juveniles in custody are affected by blood borne viruses due to high rates of risk behaviors. Therefore, they have a disproportionate burden of infectious diseases, such as hepatitis C virus (HCV) infection. The purpose of the present study was to determine prevalence and associated characteristics of hepatitis C infection in inmates of a correctional center in Isfahan, Iran.
METHODS
We conducted a cross-sectional study of HCV infection in 160 youths, who were admitted to correctional center in Isfahan during 2008-2009. Subjects were asked questions regarding behaviors that might put them at high risk for acquiring HCV and blood was drawn for this test. Sera were analyzed for HCV Ab and RIBA test was performed on antibody-positive HCV. We used Chi-square test and logistic regression model to analyze data and P < 0.05 was considered statistically significant.
RESULTS
A total of 160 young prisoners (147 boys and 13 girls) were studied. The mean age of the inmates was 16.59 ± 1.24 year. A history of intravenous drug addiction was reported in 3.8% of them. HCV infection was detected in 7 (4.4%) subjects. This study revealed that history of IDU was the main risk factor for HCV (OR, 134.44; 95% confidence interval [CI], 7.29-2481.03).
CONCLUSIONS
To prevent HCV transmission, proper drug prevention educations should be performed in young age prisoners.
目的
由于高风险行为发生率高，被拘留的青少年受到血源性病毒的影响。因此，他们承受着不成比例的传染病负担，如丙型肝炎病毒（HCV）感染。本研究的目的是确定伊朗伊斯法罕一所惩教中心囚犯中丙型肝炎感染的患病率及相关特征。
方法
我们对2008 - 2009年期间入住伊斯法罕惩教中心的160名青少年进行了丙型肝炎病毒感染的横断面研究。询问受试者可能使他们面临感染丙型肝炎病毒高风险的行为问题，并采集血液进行此项检测。对血清进行丙型肝炎病毒抗体分析，并对抗体阳性的丙型肝炎病毒进行重组免疫印迹试验（RIBA）。我们使用卡方检验和逻辑回归模型分析数据，P < 0.05被认为具有统计学意义。
结果
共研究了160名年轻囚犯（147名男孩和13名女孩）。囚犯的平均年龄为16.59 ± 1.24岁。其中3.8%的人报告有静脉注射吸毒史。7名（4.4%）受试者检测出丙型肝炎病毒感染。本研究表明，静脉注射吸毒史是丙型肝炎病毒感染的主要危险因素（比值比，134.44；95%置信区间[CI]，7.29 - 2481.03）。
结论
为预防丙型肝炎病毒传播，应在年轻囚犯中开展适当的毒品预防教育。
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