Toxicology Section, Department of Emergency Medicine, Washington University School of Medicine, St Louis, MO, USA.
Dermatitis. 2012 Jul-Aug;23(4):176-8. doi: 10.1097/DER.0b013e318262ca83.
Primary fingernail changes that result from chemical exposures are seldom encountered in clinical practice. A cluster investigation was conducted on employees at a pesticide packaging company. Six employees reported simultaneous onset of defects occurring in their fingernails, including nail discoloration, nail dimpling, and nail shedding. Multiple pesticides and herbicides including diquat were used in the facility at the time of the cluster onset. A literature review noted 6 articles published before 1975 documenting similar nail changes associated with paraquat, diquat, or other herbicide use. Only one such case report published after 1985 could be located. Diquat was the only material that was previously reported in the medical literature as causing nail defects and also in use at this facility. Diquat exposure is the most plausible explanation for the observed changes in these workers' fingernails.
在临床实践中很少会遇到由于化学暴露引起的原发性指甲变化。对一家农药包装公司的员工进行了一次群组调查。有 6 名员工报告说他们的指甲同时出现了缺陷，包括指甲变色、指甲凹陷和指甲脱落。在群组发病时，该设施使用了多种杀虫剂和除草剂，包括敌草快。文献复习发现，1975 年以前有 6 篇文献记录了与百草枯、敌草快或其他除草剂使用相关的类似指甲变化。仅找到了 1985 年后发表的一份类似病例报告。敌草快是唯一一种以前在医学文献中报道过会导致指甲缺陷的物质，而且该物质也在该设施中使用。敌草快暴露是这些工人指甲出现观察到的变化的最合理的解释。
