Risser R
Proc Natl Acad Sci U S A. 1979 Oct;76(10):5350-4. doi: 10.1073/pnas.76.10.5350.
Abelson antigen is a cell-surface determinant specifically induced by the Abelson murine leukemia virus (A-MuLV); this antigen is also expressed on uninfected bone marrow of BALB/c mice. Antisera that contained antibody to Abelson antigen were cytotoxic for the spleen colony-forming cells (CFU-S) of adult bone marrow from BALB/c mice. Absorption tests with appropriate tissues and direct cytotoxic tests with bone marrow CFU-S from several mouse strains confirmed that the sensitivity of BALB/c CFU-S to lysis by anti-Abelson-antigen antisera was due to expression of Abelson antigen. Spleen or bone marrow from BALB/c mice undergoing hematopoietic regeneration amplified Abelson antigen expression, although no expression of Abelson antigen was observed on regenerating C57BL/B6 bone marrow or spleen. The presence of Abelson antigen on bone marrow cells of seven recombinant inbred strains coincided with the inheritance of sensitivity alleles at the Av-2 locus, a gene that determines susceptibility to A-MuLV lymphoma induction. These results indicate that expression of Ableson antigen may have a physiologic function in hematopoietic differentiation and a pathologic role in A-MuLV lymphomagenesis.
阿贝尔森抗原是一种由阿贝尔森鼠白血病病毒(A-MuLV)特异性诱导产生的细胞表面决定簇;这种抗原也在未感染的BALB/c小鼠骨髓中表达。含有抗阿贝尔森抗原抗体的抗血清对BALB/c小鼠成年骨髓的脾集落形成细胞(CFU-S)具有细胞毒性。用合适的组织进行吸收试验以及对几种小鼠品系的骨髓CFU-S进行直接细胞毒性试验证实,BALB/c CFU-S对抗阿贝尔森抗原抗血清裂解的敏感性是由于阿贝尔森抗原的表达。正在进行造血再生的BALB/c小鼠的脾脏或骨髓会增强阿贝尔森抗原的表达,尽管在再生的C57BL/B6骨髓或脾脏上未观察到阿贝尔森抗原的表达。七个重组近交系的骨髓细胞上阿贝尔森抗原的存在与Av-2位点敏感性等位基因的遗传一致,Av-2位点是一个决定对A-MuLV淋巴瘤诱导易感性的基因。这些结果表明,阿贝尔森抗原的表达可能在造血分化中具有生理功能,而在A-MuLV淋巴瘤发生中具有病理作用。