来自艾贝尔森病小鼠的转化淋巴细胞表达一种与B淋巴细胞系转化相关的抗原，其水平高于正常淋巴细胞上发现的水平。
Transformed lymphocytes from Abelson-diseased mice express levels of a B lineage transformation-associated antigen elevated from that found on normal lymphocytes.
作者信息
Tidmarsh G F, Dailey M O, Whitlock C A, Pillemer E, Weissman I L
出版信息
J Exp Med. 1985 Nov 1;162(5):1421-34. doi: 10.1084/jem.162.5.1421.
Abstract
Animals injected with Abelson murine leukemia virus (A-MuLV) rapidly develop fatal bone marrow-derived lymphosarcomas. In all such diseased animals tested, a subpopulation of bone marrow cells expressed a monoclonal antibody-defined, B lineage transformation-associated antigen (6C3 Ag) at levels increased from that detected on normal lymphocytes. Cells bearing a high level of this antigen were found to be transformed as measured by clonal growth in agar, and they expressed surface antigen markers characteristic of early pre-B cells. High-level antigen-expressing cells were found in the bone marrow, lymph nodes, and spleen, but never in the thymus of diseased animals. This distribution agrees with the published pathology of Abelson disease.
摘要
注射了阿贝尔逊鼠白血病病毒（A-MuLV）的动物会迅速发展为致命的骨髓源性淋巴瘤。在所有检测的此类患病动物中，骨髓细胞亚群表达一种单克隆抗体定义的、与B系转化相关的抗原（6C3抗原），其水平高于正常淋巴细胞上检测到的水平。通过在琼脂中的克隆生长测定，发现携带高水平这种抗原的细胞已发生转化，并且它们表达早期前B细胞特有的表面抗原标志物。在患病动物的骨髓、淋巴结和脾脏中发现了高水平表达抗原的细胞，但在胸腺中从未发现。这种分布与已发表的阿贝尔逊病病理学一致。
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1
Transformed lymphocytes from Abelson-diseased mice express levels of a B lineage transformation-associated antigen elevated from that found on normal lymphocytes.来自艾贝尔森病小鼠的转化淋巴细胞表达一种与B淋巴细胞系转化相关的抗原，其水平高于正常淋巴细胞上发现的水平。
J Exp Med. 1985 Nov 1;162(5):1421-34. doi: 10.1084/jem.162.5.1421.
2
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Expression of a monoclonal antibody-defined, B-lineage transformation antigen specifically identifies Abelson-diseased animals. Genetically determined resistance to Abelson murine leukemia virus acts before induction of gp160(6C3).一种单克隆抗体定义的B系转化抗原的表达可特异性识别艾贝尔森病动物。对艾贝尔森鼠白血病病毒的遗传抗性在gp160(6C3)诱导之前起作用。
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Transformation by Abelson murine leukemia virus: properties of the transformed cells.阿贝尔森鼠白血病病毒介导的转化：转化细胞的特性
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Early B-cell precursors in scid mice: normal numbers of cells transformable with Abelson murine leukemia virus (A-MuLV).严重联合免疫缺陷（scid）小鼠中的早期B细胞前体：可被Abelson鼠白血病病毒（A-MuLV）转化的正常细胞数量。
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引用本文的文献
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Expression of the 6C3 antigen on murine hematopoietic neoplasms. Association with expression of abl, ras, fes, src, erbB, and Cas NS-1 oncogenes but not with myc.6C3抗原在小鼠造血系统肿瘤中的表达。与abl、ras、fes、src、erbB和Cas NS-1癌基因的表达相关，但与myc癌基因的表达无关。
J Exp Med. 1987 Mar 1;165(3):920-5. doi: 10.1084/jem.165.3.920.
2
Expression of a monoclonal antibody-defined, B-lineage transformation antigen specifically identifies Abelson-diseased animals. Genetically determined resistance to Abelson murine leukemia virus acts before induction of gp160(6C3).一种单克隆抗体定义的B系转化抗原的表达可特异性识别艾贝尔森病动物。对艾贝尔森鼠白血病病毒的遗传抗性在gp160(6C3)诱导之前起作用。
J Exp Med. 1986 Oct 1;164(4):1356-61. doi: 10.1084/jem.164.4.1356.
3
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Murine hematopoietic cells with pre-B or pre-B/myeloid characteristics are generated by in vitro transformation with retroviruses containing fes, ras, abl, and src oncogenes.具有前B细胞或前B细胞/髓系特征的小鼠造血细胞是通过用含有fes、ras、abl和src癌基因的逆转录病毒进行体外转化而产生的。
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One-step purification of mouse monoclonal antibodies from ascitic fluid by DEAE Affi-Gel blue chromatography.通过DEAE亲和蓝胶色谱法从腹水原液中一步纯化小鼠单克隆抗体。
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Transformation-associated proteins in murine B-cell lymphomas that are distinct from Abelson virus gene products.与阿贝尔森病毒基因产物不同的小鼠B细胞淋巴瘤中的转化相关蛋白。
Proc Natl Acad Sci U S A. 1984 Jul;81(14):4434-8. doi: 10.1073/pnas.81.14.4434.
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Abelson virus-infected cells can exhibit restricted in vitro growth and low oncogenic potential.艾贝尔逊病毒感染的细胞在体外可能表现出生长受限和致癌潜力较低的情况。
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Characterization of Y73, an avian sarcoma virus: a unique transforming gene and its product, a phosphopolyprotein with protein kinase activity.禽肉瘤病毒Y73的特性：一种独特的转化基因及其产物，一种具有蛋白激酶活性的磷酸化多蛋白。
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Structure and expression of the Abelson murine leukemia virus genome and its relationship to a normal cell gene.阿贝尔逊鼠白血病病毒基因组的结构与表达及其与正常细胞基因的关系。
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Murine leukaemogenesis: monoclonal antibodies to T-cell determinants arrest T-lymphoma cell proliferation.小鼠白血病发生：针对T细胞决定簇的单克隆抗体可阻止T淋巴瘤细胞增殖。
Nature. 1980 May 22;285(5762):259-61. doi: 10.1038/285259a0.
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Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity.禽肉瘤病毒UR2编码一种与独特蛋白激酶活性相关的转化蛋白。
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Localization of the Abelson murine leukemia virus protein in a detergent-insoluble subcellular matrix: architecture of the protein.阿贝尔逊鼠白血病病毒蛋白在去污剂不溶性亚细胞基质中的定位：蛋白结构
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Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras.辐射骨髓嵌合体胸腺细胞上出现意外宿主MHC决定簇的细胞表面表现。
J Immunol. 1981 Apr;126(4):1327-35.
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