Department of Paediatrics, Tampere University Hospital, Tampere, Finland.
Amino Acids. 2013 Feb;44(2):533-42. doi: 10.1007/s00726-012-1368-x. Epub 2012 Jul 25.
Taurine has been thought to protect neural cells against cell-damaging conditions to which the hippocampus is particularly vulnerable. We studied now how the release of preloaded [(3)H]taurine is regulated by glutamate receptors in glucose-free media in slices prepared from the mouse hippocampus from developing (7 days old) and young adult (3 months old) mice, using a superfusion system. The lack of glucose enhanced taurine release more from slices from developing mice than from slices from adults. At both ages ionotropic glutamate agonists significantly increased the release in a receptor-mediated manner. Of the metabotropic glutamate receptors those belonging to the group III were effective. The release was enhanced in adult mice but attenuated in developing mice. Both effects were blocked by the receptor antagonists. The results show that glutamate receptors affect taurine release in the absence of glucose in which condition taurine should be neuroprotective.
牛磺酸被认为可以保护海马体等易受损伤的神经细胞免受细胞损伤。我们现在研究了在无糖培养基中，谷氨酸受体是如何调节从小鼠海马体切片中预先加载的[(3)H]牛磺酸释放的，使用的是一种超滤液系统。在无糖培养基中，发育中的（7 日龄）小鼠的切片中牛磺酸的释放比成年（3 月龄）小鼠的切片中牛磺酸的释放增强得更多。在这两个年龄段，离子型谷氨酸受体以受体介导的方式显著增加了释放。代谢型谷氨酸受体中属于第三组的受体是有效的。在成年小鼠中，释放增强，而在发育中的小鼠中，释放减弱。这两种作用都被受体拮抗剂阻断。结果表明，在缺乏葡萄糖的情况下，谷氨酸受体影响牛磺酸的释放，在这种情况下，牛磺酸应该具有神经保护作用。
