Department of Anatomy, College of Medicine, Kyung Hee University, Dongdaemun-Gu, Seoul, Republic of Korea.
Oxid Med Cell Longev. 2012;2012:718976. doi: 10.1155/2012/718976. Epub 2012 Jul 5.
Aging is associated with neuronal loss, gross weight reduction of the brain, and glial proliferation in the cortex, all of which lead to functional changes in the brain. It is known that oxidative stress is a critical factor in the pathogenesis of aging; additionally, growing evidence suggests that excessive nitric oxide (NO) production contributes to the aging process. However, it is still unclear how NO plays a role in the aging process. This paper describes age-related changes in the activity of NADPH-diaphorase (NADPH-d), a marker for neurons containing nitric oxide synthase (NOS), in many CNS regions. Understanding these changes may provide a novel perspective in identifying the aging mechanism.
衰老是与神经元缺失、大脑总体重量减轻以及大脑皮层神经胶质增生相关的，所有这些都会导致大脑功能的变化。已知氧化应激是衰老发病机制中的一个关键因素；此外，越来越多的证据表明，过量的一氧化氮（NO）产生会导致衰老过程。然而，NO 如何在衰老过程中发挥作用仍不清楚。本文描述了 NADPH-黄递酶（NADPH-d）活性的年龄相关性变化，NADPH-d 是一种标记物，用于标记含有一氧化氮合酶（NOS）的神经元，这种变化存在于中枢神经系统的许多区域中。了解这些变化可能为确定衰老机制提供新的视角。
