在正常人群中，比较使用冻干和商业食物过敏原提取物进行斑贴试验的刺激性反应。

Comparison of irritatant reactions between using lyophilized and commercial food allergen extracts in atopy patch tests in a normal population.

机构信息

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkoknoi, Bangkok 10700, Thailand.

出版信息

Asian Pac J Allergy Immunol. 2012 Jun;30(2):158-61.

PMID:22830296

Abstract

BACKGROUND

Several authors have investigated the use of the atopy patch tests (APT) for the diagnosis of non-IgE mediated food allergy, primarily in patients with atopic dermatitis and digestive disorders. However, one of the difficulties in atopy patch testing is the lack of standardization. Several commercial APTs containing freeze-dried food extracts are now available, but their diagnostic accuracy is still largely undefined. The objective of this study is to evaluate the irritant reactions and safety of atopy patch tests in healthy subjects by using lyophilized and commercial food allergen extracts.

METHODS

A cross-sectional study was carried out in healthy volunteers. Atopy patches using lyophilized and commercial allergens, including cow's milk, egg, wheat, soy and shrimp, were assessed. Additionally, commercial extracts of house dust mite (D. pteronyssinus 10,000 AU/ml, D. farinae 10,000 AU/ml) and American cockroach were also evaluated.

RESULTS

Eighteen healthy volunteers (13 women, median age 26 years) were enrolled. All APT results, both from using lyophilized and commercial allergen extracts, showed no reactions. There were no systemic allergic reactions or irritant reactions observed.

CONCLUSION

APTs using lyophilized and commercial food allergen extracts and commercial extracts of house dust mite and American cockroach showed no irritant reactions in Thai non-atopic subjects.

摘要

背景

已有多位作者研究过使用变应原斑贴试验（APT）来诊断非 IgE 介导的食物过敏，主要针对特应性皮炎和消化道疾病患者。然而，变应原斑贴试验的一个难点是缺乏标准化。现在有几种含有冻干食物提取物的商业 APT 可用，但它们的诊断准确性在很大程度上仍未得到明确。本研究旨在评估使用冻干和商业食物过敏原提取物进行变应原斑贴试验在健康受试者中的刺激性反应和安全性。