Department of Orthopaedic Surgery, Cancer Institute Hospital for Japanese Foundation for Cancer Research, Koto-ku, Tokyo, Japan.
BMC Cancer. 2012 Jul 25;12:313. doi: 10.1186/1471-2407-12-313.
Soft tissue metastases, in particular intraneural metastasis, from any carcinomas seldom occur. To our knowledge, no case of sciatic nerve palsy due to intraneural metastasis of gastric carcinoma is reported in the literature.
A case is reported of a 82-year old woman with sciatic nerve palsy with intraneural metastasis of gastric carcinoma. Although she had undergone partial gastrectomy with T2b, N0, M0 two years ago and primary site was cured, she developed sciatic nerve palsy from the carcinoma metastasis directly to the nerve. Operative resection and Histological examination revealed poorly differentiated adenocarcinoma, the same as her primary site adenocarcinoma.
Sciatica is usually caused by a herniated disc or spinal canal stenosis. Sciatic nerve palsy may be caused by nondiscogenic etiologies that may be either intrapelvic or extrapelvic. It is important to image the entire course of the nerve to distinguish these etiologies quickly. The longer the nerve compression the less likely a palsy will recover. Surgery is a good intervention that simultaneously obtains a tissue diagnosis and decompresses the nerve.
软组织转移,特别是神经内转移,来自任何癌症的情况都很少见。据我们所知,文献中没有报道过胃癌神经内转移导致坐骨神经麻痹的病例。
报告了一例 82 岁女性因胃癌神经内转移导致坐骨神经麻痹。尽管她两年前因 T2b、N0、M0 行部分胃切除术且原发灶已治愈,但仍因肿瘤直接转移至神经而发生坐骨神经麻痹。手术切除和组织学检查显示低分化腺癌,与原发部位的腺癌相同。
坐骨神经痛通常由椎间盘突出或椎管狭窄引起。坐骨神经麻痹可能由非椎间盘源性病因引起,这些病因可能位于骨盆内或骨盆外。重要的是要对神经的整个行程进行成像,以快速区分这些病因。神经受压时间越长,麻痹恢复的可能性越小。手术是一种很好的干预措施,它可以同时获得组织诊断并对神经进行减压。