Boyd Alan S, Hayes Benjamin B
Department of Medicine (Dermatology), Vanderbilt University, Nashville, TN 37204, USA.
J Cutan Pathol. 2012 Nov;39(11):1042-6. doi: 10.1111/j.1600-0560.2012.01970.x. Epub 2012 Jul 25.
Cutaneous metastases from internal malignancies in women overwhelmingly emanate from the breast and typically exhibit features of an adenocarcinoma, although other histopathologic patterns may also be seen. Neuroendocrine breast carcinoma represents an uncommon variant of mammary carcinoma with fewer than 40 cases of the small cell subcategory reported. As with other small cell carcinomas, they may exhibit Merkel cell-like features and appropriate diagnosis of these tumor deposits often turns on clinical history and an appropriate immunohistochemical profile. Herein, we report the first known patient with cutaneous metastases from a small cell neuroendocrine breast carcinoma.
女性体内恶性肿瘤的皮肤转移绝大多数源自乳腺，通常表现为腺癌特征，不过也可见其他组织病理学模式。神经内分泌性乳腺癌是一种罕见的乳腺癌变体，据报道小细胞亚型病例不足40例。与其他小细胞癌一样，它们可能呈现默克尔细胞样特征，对这些肿瘤沉积物的准确诊断往往取决于临床病史和合适的免疫组化特征。在此，我们报告首例已知的小细胞神经内分泌性乳腺癌皮肤转移患者。
