疟疾传播季节期间健康个体的细胞免疫反应性降低。
Reduced cellular immune reactivity in healthy individuals during the malaria transmission season.
作者信息
Theander T G, Hviid L, Abu-Zeid Y A, Abdulhadi N H, Saeed B O, Jakobsen P H, Reimert C M, Jepsen S, Bayoumi R A, Jensen J B
机构信息
Department of Infectious Diseases, State University Hospital, Copenhagen, Denmark.
出版信息
Immunol Lett. 1990 Aug;25(1-3):237-42. doi: 10.1016/0165-2478(90)90121-6.
Antigen-induced cellular immune responses are suppressed during acute malaria. The present study engages the possibility that malaria-induced alterations in cellular immune reactivity extend beyond the clinical disease. Thus, lymphoproliferative responses of healthy individuals were diminished during the malaria transmission period in individuals living in an area of highly seasonal, unstable malaria transmission. This finding may have important implications for the design of studies of stimulatory properties of antigens using lymphocytes of endemic origin.
在急性疟疾期间，抗原诱导的细胞免疫反应受到抑制。本研究探讨了疟疾诱导的细胞免疫反应性改变可能超出临床疾病范围的可能性。因此，在季节性强、疟疾传播不稳定地区生活的个体，在疟疾传播期间，其淋巴细胞增殖反应减弱。这一发现可能对抗原刺激特性研究设计有重要意义，此类研究使用的是来自流行地区的淋巴细胞。
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