Division of Ophthalmology, Department of Neurosciences, University of the Witwatersrand, Johannesburg, South Africa.
S Afr Med J. 2012 Jun 28;102(8):687-90. doi: 10.7196/samj.5930.
The relative importance of environmental and hereditary factors in the occurrence of pterygium in African blacks has not been reported.
To investigate the relative significance of factors associated with pterygium occurrence.
This was a prospective case-controlled study where 150 pterygium patients and 150 controls participated. Interviews were conducted, eyes examined and multivariate analysis done. The families of 51 pterygium cases and 50 controls were examined for presence of pterygium.
Of 150 cases and 150 controls, 79 (52.6%) and 60 (40%) used traditional eye drops (odds ratio (OR) 2.03; p=0.009. Ten cases (6.6%) and 26 controls (17.3%) had unstable tear film (OR 0.30; p=0.007. Forty-six cases (30.6%) and 15 controls (10%) reported a positive family history (OR 3.93; p<0.001). Groups of 3 - 5 pterygium cases in a household occurred in 36 of 51 pterygium families (70.5%) v. 1 of 50 controls (2%).
Pterygium occurrence was associated with the use of traditional eye drops, a positive family history and having groups of diagnosed pterygium-affected relatives. However, unstable tear film seemed protective against pterygium occurrence.
环境和遗传因素在非洲黑人中翼状胬肉发生中的相对重要性尚未报道。
研究与翼状胬肉发生相关的因素的相对意义。
这是一项前瞻性病例对照研究，共有 150 例翼状胬肉患者和 150 例对照者参与。进行了访谈、眼部检查和多变量分析。对 51 例翼状胬肉病例和 50 例对照者的家庭进行了翼状胬肉的存在检查。
在 150 例病例和 150 例对照者中，79 例（52.6%）和 60 例（40%）使用传统眼药水（比值比（OR）2.03；p=0.009）。10 例（6.6%）和 26 例对照者（17.3%）有不稳定的泪膜（OR 0.30；p=0.007）。46 例（30.6%）和 15 例对照者（10%）报告有阳性家族史（OR 3.93；p<0.001）。在 51 个翼状胬肉家庭中，有 36 个家庭（70.5%）有 3-5 个翼状胬肉患者，而 50 个对照者中有 1 个（2%）。
翼状胬肉的发生与使用传统眼药水、阳性家族史和有确诊的翼状胬肉受累亲属群体有关。然而，不稳定的泪膜似乎对翼状胬肉的发生有保护作用。
