The Aga Khan University Hospital, Department of Pathology and Microbiology, Karachi, Pakistan.
Ann Diagn Pathol. 2013 Feb;17(1):54-7. doi: 10.1016/j.anndiagpath.2012.06.001. Epub 2012 Jul 23.
Our aim was to describe clinicopathologic features of secretory carcinoma on a cohort of cases. We retrieved reported cases of secretory carcinoma of breast (SCB) in the Section of Histopathology, Department of Pathology & Microbiology, Aga Khan University Hospital Karachi, from May 2004 to December 2011. The slides were reviewed, and clinicopathologic features were noted. A total of 8 cases of SCB were found. The age ranged from 17 to 60 years (median, 41 years) with a female to male ratio of 7:1. Lumpectomy was done in 6 cases, and mastectomy, in 2 cases. The tumor size ranged from 2.5 to 10 cm (mean, 5.5 cm). Histologically, abundant extra- and intracellular secretory material was seen in all cases. Most of the tumors showed mixtures of patterns with dominant microcystic and papillary patterns. In situ component was seen in only 1 case. Lymph node metastases were seen in both cases with lymph node sampling. In conclusion, SCB is a rare type of ductal breast carcinoma. The papillary pattern of SCB is rare according to published data but was seen in most of our cases. In situ secretory carcinoma is even rarer, and to date, we have seen a single case only. Although most occur in women, these can be seen in men as well.
我们的目的是描述一组分泌性乳腺癌病例的临床病理特征。我们检索了 2004 年 5 月至 2011 年 12 月在卡拉奇阿迦汗大学医院病理学与微生物学部组织病理学科报告的乳腺分泌性癌病例。我们复习了切片，并记录了临床病理特征。共发现 8 例分泌性乳腺癌。年龄 17 至 60 岁（中位数 41 岁），女性与男性比例为 7:1。6 例患者行肿块切除术，2 例行乳房切除术。肿瘤大小 2.5 至 10 厘米（平均 5.5 厘米）。所有病例均可见丰富的细胞外和细胞内分泌物质。大多数肿瘤显示多种模式的混合，以微囊状和乳头状模式为主。仅有 1 例可见原位成分。有淋巴结取样的 2 例病例均有淋巴结转移。总之，分泌性乳腺癌是一种罕见的乳腺导管癌。根据已发表的数据，分泌性乳腺癌的乳头状模式较为罕见，但在我们的大多数病例中均可见。原位分泌性癌更为罕见，迄今为止，我们仅见到 1 例。尽管大多数发生在女性中，但男性也可能发生。
