Pathology Unit, Department of Clinical Services, Santa Chiara Hospital, Trento, Italy.
Department of Pathology, Pendik Research Training Hospital, Marmara University, Muhsin Yazicioglu Cad. No: 10, Pendik, 34899, Istanbul, Turkey.
Virchows Arch. 2022 Jan;480(1):109-126. doi: 10.1007/s00428-021-03174-7. Epub 2021 Aug 30.
Triple-negative breast carcinomas constitute a wide spectrum of lesions, mostly being highly aggressive. Nevertheless, some special histologic subtypes can have low malignant potential. The purpose of the present paper is to review diagnostic criteria and prognostic parameters of breast neoplasms of special histotypes. Specifically, adenoid cystic carcinoma, adenomyoepithelioma, acinic cell carcinoma, mucoepidermoid carcinoma, tall cell carcinoma with reverse polarity, and secretory carcinoma will be discussed. For each tumour, definition and morphological and molecular features, together with prognostic parameters, will be presented. Paradigmatic cases will be illustrated.
三阴性乳腺癌是一组广泛存在的病变,大多具有高度侵袭性。然而,一些特殊的组织学亚型可能具有低恶性潜能。本文旨在回顾特殊组织学类型乳腺肿瘤的诊断标准和预后参数。具体来说,将讨论腺样囊性癌、腺肌上皮瘤、腺泡细胞癌、黏液表皮样癌、极性反转的高细胞癌和分泌癌。对于每种肿瘤,将介绍其定义、形态学和分子特征以及预后参数。将举例说明典型病例。