Marchi S, Polloni A, Costa F, Bellini M, Bonifazi V, Tumino E, Grassi B, Romano M R, De Bartolo G, Bertelli A
First Medical Clinic, University of Pisa, Italy.
Int J Tissue React. 1990;12(4):247-50.
Hepatoprotective actions of metadoxina and ubiquinone have been studied in alcoholic rats by evaluating hepatic triglyceride accumulation and serum biochemical parameters of liver function. The two drug-treated groups displayed significantly lower triglyceride concentrations as compared to the ethanol-treated group. No significant differences were found among the two drug-treated and the control groups. Electron-microscopic abnormalities were found only in ethanol-treated rats. Serum biochemical parameters of liver function did not show any significant difference among all four groups. These results suggest a possible protective role of metadoxina and ubiquinone in ethanol-induced liver triglyceride accumulation.
通过评估肝脏甘油三酯蓄积情况和肝功能的血清生化参数，研究了美他多辛和辅酶Q在酒精性大鼠中的肝脏保护作用。与乙醇处理组相比，两个药物处理组的甘油三酯浓度显著降低。在两个药物处理组和对照组之间未发现显著差异。仅在乙醇处理的大鼠中发现电子显微镜下的异常。所有四组的肝功能血清生化参数均未显示出任何显著差异。这些结果表明美他多辛和辅酶Q在乙醇诱导的肝脏甘油三酯蓄积中可能具有保护作用。
