Department of Rheumatology, Hospital of Southern Norway, Kristiansand, Norway.
J Clin Rheumatol. 2012 Sep;18(6):310-1. doi: 10.1097/RHU.0b013e31826149a2.
A 54-year-old woman with recurrent episodes of bilateral knee arthritis was admitted several times to the Department of Rheumatology. She was diagnosed to have chronic calcium pyrophosphate crystal arthritis. Interleukin 1β (IL-1β) plays a central role in the pathogenesis of inflammation induced by calcium pyrophosphate crystals, and IL-1β blockade may be an effective treatment in patients with severe chronic calcium pyrophosphate crystal arthritis. Because of the short effect of treatment with corticosteroids and the frequent attacks of arthritis, the patient was treated with the IL-1 receptor antagonist anakinra. She responded well after 1 week with normalization of inflammation. Eight months after the initiation of treatment, the patient has had no relapses, although we were unable to withdraw the anakinra.
一位 54 岁的女性反复出现双侧膝关节关节炎，多次入住风湿科。她被诊断为慢性焦磷酸钙晶体关节炎。白细胞介素 1β（IL-1β）在焦磷酸钙晶体诱导的炎症发病机制中起核心作用，IL-1β 阻断可能是治疗严重慢性焦磷酸钙晶体关节炎的有效方法。由于皮质类固醇治疗效果短暂，关节炎频繁发作，患者接受了白细胞介素 1 受体拮抗剂阿那白滞素治疗。治疗 1 周后炎症恢复正常，患者反应良好。治疗开始后 8 个月，尽管我们无法停用阿那白滞素，但患者未再复发。
