McGonagle Dennis, Tan Ai Lyn, Madden Julie, Emery Paul, McDermott Michael F
Calderdale Royal Hospital, Halifax, UK.
Arthritis Rheum. 2008 Feb;58(2):631-3. doi: 10.1002/art.23119.
We describe herein the case of a 63-year-old man with pseudogout affecting multiple joints that was resistant to treatment with allopurinol, steroids, and antiinflammatory drugs. Based on recent data on the molecular mechanism of pseudogout that demonstrated overproduction of interleukin-1 (IL-1), we treated the patient with anakinra, an IL-1 receptor antagonist. The patient responded to treatment with anakinra within 2 weeks, with resolution of the signs and symptoms of pseudogout and normalization of levels of inflammation markers.
我们在此描述了一名63岁男性的病例，其患有影响多个关节的假性痛风，对别嘌醇、类固醇和抗炎药治疗均有抵抗。基于最近关于假性痛风分子机制的数据表明白细胞介素-1（IL-1）产生过多，我们用阿那白滞素（一种IL-1受体拮抗剂）对该患者进行治疗。患者在2周内对阿那白滞素治疗产生反应，假性痛风的体征和症状消退，炎症标志物水平恢复正常。
