氟代吡唑啉衍生物的绿色合成及抗感染活性研究。
Green synthesis and anti-infective activities of fluorinated pyrazoline derivatives.
机构信息
Department of Chemistry, SSGM College, Kopargaon, Dist-Ahmednagar (MH) 423601, India.
出版信息
Bioorg Med Chem Lett. 2012 Sep 1;22(17):5727-30. doi: 10.1016/j.bmcl.2012.06.072. Epub 2012 Jul 6.
PMID:22832312
Abstract
A new series of fluorinated pyrazoles, 4a-e, were synthesized in good to excellent overall yields (65-82%) from the corresponding chalcones, 3a-e, by ultrasonic irradiation. The newly synthesized compounds were characterized and screened for their in vitro anti-bacterial, anti-fungal, and anti-tubercular activities against Mycobacterium tuberculosis H(37)Rv.
摘要
通过超声辐射，从相应的查尔酮 3a-e 出发，以良好到优异的总收率（65-82%）合成了一系列新的氟化吡唑 4a-e。新合成的化合物进行了表征，并对其进行了体外抗细菌、抗真菌和抗结核分枝杆菌 H(37)Rv 的活性筛选。
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