Medicinal Chemistry Laboratory, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, Morocco.
LCAE, Department of Chemistry, Faculty of Sciences, University Mohamed I, 60000 Oujda, Morocco.
Molecules. 2018 Jan 12;23(1):134. doi: 10.3390/molecules23010134.
Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.
吡唑及其衍生物被认为是一种具有重要药理活性的基本结构，具有几乎所有类型的药理活性。在不同治疗类别的药物中都存在这个核，如塞来昔布（一种强效抗炎药）、CDPPB（一种抗精神病药）、利莫那班（一种减肥药）、地芬那酯（一种镇痛药）、贝他唑啉（一种 H2 受体激动剂）和非甾体类抗抑郁药 fezolamide，这证明了吡唑部分的药理潜力。由于其在生物领域的多样性，这个核已经吸引了许多研究人员从化学和生物学方面来研究其结构。本文综述了吡唑衍生物的不同合成方法和药理性质。报道了全球许多科学家对吡唑衍生物的合成和生物活性的研究。
