简化大环内酯类抗生素埃他卡林侧链的设计、合成与生物评价。
Design, synthesis and biological evaluation of simplified side chains of the macrolide antibiotic etnangien.
机构信息
Organische Chemie, Ruprecht-Karls-Universität Heidelberg, INF 270, D-69120 Heidelberg, Germany.
出版信息
Bioorg Med Chem Lett. 2012 Sep 1;22(17):5731-4. doi: 10.1016/j.bmcl.2012.06.070. Epub 2012 Jul 14.
PMID:22832317
Abstract
Novel simplified side chains of the potent RNA polymerase inhibitor etnangien were designed, synthesized and evaluated for antibacterial activity against Gram-positive bacteria and one Gram-negative bacterium.
摘要
设计、合成并评估了具有强效 RNA 聚合酶抑制剂依替米星的新型简化侧链，以评估其对革兰氏阳性菌和一种革兰氏阴性菌的抗菌活性。
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