通过闭环复分解反应获得被跳过的多烯大环内酯：RNA 聚合酶抑制剂利帕他汀 B 的全合成。
Access to skipped polyene macrolides through ring-closing metathesis: total synthesis of the RNA polymerase inhibitor ripostatin B.
机构信息
TU Dortmund University, Faculty of Chemistry, Germany.
出版信息
Angew Chem Int Ed Engl. 2012 Apr 2;51(14):3396-400. doi: 10.1002/anie.201108692. Epub 2012 Feb 15.
PMID:22337614
Abstract
Rip-Roaring! A convergent total synthesis of antibiotic ripostatin B was developed. A key step in the synthesis is a metathesis reaction allowing for a ring closure to the labile doubly skipped triene macrolide.
摘要
呼啸而过！抗生素里波他汀 B 的汇聚式全合成被开发出来。合成过程中的关键步骤是一个复分解反应，允许不稳定的双缺失三烯大环内酯进行环化。
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