Department of Gynaecological Oncology/Jessop Wing Colposcopy Unit, Sheffield Hospitals NHS Trust, Sheffield, UK.
Int J Gynecol Pathol. 2012 Sep;31(5):470-4. doi: 10.1097/PGP.0b013e31824a1d8d.
To assess the management and outcome for women with microinvasive cervical cancer with stromal invasion 1 mm or less, examining the impact of re-excision. A retrospective cohort study with interval analysis performed between December 2000 and December 2010. Sheffield Gynaecological Cancer Centre and Jessop Wing Colposcopy Unit, Sheffield, UK. Women diagnosed with microinvasive cervical cancer with stromal invasion 1 mm or less during the allocated study period. Methods used is a retrospective cohort study. Risk of recurrence and mortality from disease; incidence of residual disease in repeat excision specimens. A total of 140 women were identified as having microinvasive cervical cancer with stromal invasion 1 mm or less. Sixty-three (45%) had a completely excised lesion; 77 (55%) had an incompletely excised lesion at first treatment. Fifty-five women underwent repeat excision. No residual disease was found in the majority (n=40; 73%). No women suffered disease recurrence or died from disease during the allocated study period. Outcome for women with microinvasive cervical cancer with stromal invasion 1 mm or less is excellent. Repeat excision is associated with very low rates of residual disease. A more conservative approach to follow-up incorporating HPV testing should be explored.
评估间质浸润 1mm 或以下的微小浸润性宫颈癌患者的管理和结局，检查再次切除的影响。这是一项回顾性队列研究，在 2000 年 12 月至 2010 年 12 月期间进行了间隔分析。英国谢菲尔德妇科癌症中心和杰索普翼阴道镜单位。在分配的研究期间诊断为间质浸润 1mm 或以下的微小浸润性宫颈癌的女性。使用的方法是回顾性队列研究。疾病复发和死亡的风险；重复切除标本中残留疾病的发生率。共确定了 140 名患有间质浸润 1mm 或以下的微小浸润性宫颈癌的女性。63 名（45%）的病变完全切除；77 名（55%）的病变在初次治疗时未完全切除。55 名妇女接受了重复切除。大多数（n=40；73%）未发现残留疾病。在分配的研究期间，没有妇女因疾病复发或死于疾病。间质浸润 1mm 或以下的微小浸润性宫颈癌患者的结局非常好。重复切除与残留疾病的发生率非常低有关。应该探索一种更保守的随访方法，包括 HPV 检测。
