Department of Chemical and Biological Engineering, Princeton University, NJ 08544, USA.
Nat Prod Rep. 2012 Sep;29(9):996-1006. doi: 10.1039/c2np20070h. Epub 2012 Jul 25.
Lasso peptides are a class of ribosomally-synthesized and posttranslationally-modified natural products with diverse bioactivities. This review describes the structure and function of all known lasso peptides (as of mid-2012) and covers our current knowledge about the biosynthesis of those molecules. The isolation and characterization of lasso peptides are also covered as are bioinformatics strategies for the discovery of new lasso peptides from genomic sequence data. Several studies on the engineering of new or improved function into lasso peptides are highlighted, and unanswered questions in the field are also described.
套索肽是一类核糖体合成并经翻译后修饰的天然产物，具有多种生物活性。本文综述了截至 2012 年年中所有已知套索肽的结构和功能，并涵盖了我们目前对这些分子生物合成的了解。本文还介绍了套索肽的分离和鉴定，以及从基因组序列数据中发现新套索肽的生物信息学策略。本文重点介绍了对套索肽进行新型或改进功能设计的几项研究，并描述了该领域尚未解决的问题。
