Kolahdoozan Melika, Jahanian-Najafabadi Ali
Bioinformatics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Pharmaceutical Biotechnology, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
World J Microbiol Biotechnol. 2025 Apr 28;41(5):151. doi: 10.1007/s11274-025-04374-y.
Lasso peptides, a significant group of ribosomally synthesized and post-translationally modified peptides (RiPPs), have emerged as potential therapeutic agents owing to their unique structural features and diverse biological activities. These peptides are characterized by an isopeptide-bonded macrolactam ring and a tail threaded through the ring, forming a distinctive lasso structure that provides remarkable stability and functionality, leading to significant therapeutic potential for antimicrobial, antiviral, anticancer, and anti-inflammatory applications. This review highlights the structural diversity and therapeutic applications of lasso peptides, emphasizing their potential as next-generation therapeutics. Additionally, while their mechanisms of action and innovative therapeutic prospects are explored, the challenges and limitations associated with their use are also discussed.
套索肽是核糖体合成并经翻译后修饰的肽（RiPPs）中的一个重要类别，由于其独特的结构特征和多样的生物活性，已成为潜在的治疗剂。这些肽的特征在于异肽键连接的大环内酯环和穿过该环的尾巴，形成独特的套索结构，该结构具有出色的稳定性和功能性，从而在抗菌、抗病毒、抗癌和抗炎应用方面具有巨大的治疗潜力。本综述重点介绍了套索肽的结构多样性和治疗应用，强调了它们作为下一代治疗剂的潜力。此外，在探讨其作用机制和创新治疗前景的同时，也讨论了与它们使用相关的挑战和局限性。
