Department of Pediatrics, Division of Newborn Medicine, Gazi University Hospital, Yesilyurt Sokak 19/9 Cankaya, Ankara 06690, Turkey.
Arch Dis Child Fetal Neonatal Ed. 2013 Mar;98(2):F155-7. doi: 10.1136/archdischild-2012-301647. Epub 2012 Jul 25.
Hypothermia is becoming a common treatment for newborns with hypoxic ischaemic encephalopathy. Cerebral metabolic effects have been studied extensively. However, acute effects on peripheral microcirculation are unknown. The effects of therapeutic hypothermia on peripheral microcirculation assessed by side-stream dark field (SDF) imaging technique are presented.
Peripheral microcirculation was assessed in seven newborns undergoing selective head-cooling treatment with SDF imaging video recordings during core temperature 34°C, and then after re-warming at 37°C, and also in seven control patients with rectal temperature 37°C. Microvascular flow index (MFI) and per cent of vessels with sluggish flow were determined by using appropriate software.
Sluggish microcirculation was observed during hypothermia compared with controls. MFI and per cent of vessels with sluggish flow returned to normal after re-warming.
The results of this small group of newborns going through therapeutic hypothermia suggests that microcirculation is effected with this treatment. Whether this finding has other clinical impacts requires further research.
低温疗法正成为治疗患有缺氧缺血性脑病新生儿的常用方法。人们对其脑部代谢的影响进行了广泛研究。然而，其对周围微循环的急性影响尚不清楚。本研究采用侧流暗场成像（SDF）技术，对低温治疗对周围微循环的影响进行了评估。
对 7 名接受选择性头部降温治疗的新生儿进行了研究，在核心温度达到 34°C 时，用 SDF 成像视频记录外周微循环，并在 7 名直肠温度为 37°C 的对照组患者中进行了记录。使用适当的软件确定微血管血流指数（MFI）和血流缓慢的血管比例。
与对照组相比，低温治疗时观察到微循环缓慢。复温后，MFI 和血流缓慢的血管比例恢复正常。
该组接受低温治疗的新生儿的结果表明，该治疗会影响微循环。这一发现是否具有其他临床影响，还需要进一步研究。
