Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Laryngoscope. 2012 Aug;122(8):1690-4. doi: 10.1002/lary.22419.
OBJECTIVES/HYPOTHESIS: Mucoepidermoid carcinoma (MEC) with MAML2 translocation is believed to be associated with lower clinical stage, lower histologic grade, and better outcome. We summarized our prospective experience testing MEC for the MAML2 translocation.
Prospective cohort study.
One hundred eighteen head and neck tumors (55 MECs and 63 mimics) were prospectively tested for MAML2 translocation by fluorescence in situ hybridization as part of clinical care during a 36-month period.
MAML2 translocation was identified in 41 of 55 (75%) cases diagnosed as MEC. Translocation status did not correlate significantly with histologic grade, age, gender, tumor site, or T stage.
Routine testing for MAML2 translocation by fluorescence in situ hybridization is feasible and useful in confirming the diagnosis of MEC. The lack of significant correlation with histologic grade or pathologic stage implies that the previously reported prognostic value of the MAML2 translocation may be an artifact of misclassification of MEC as other tumors.
目的/假说：具有 MAML2 易位的黏液表皮样癌（MEC）被认为与较低的临床分期、较低的组织学分级和更好的预后相关。我们总结了我们对 MEC 进行 MAML2 易位检测的前瞻性经验。
前瞻性队列研究。
在 36 个月的临床护理过程中，作为常规临床护理的一部分，118 例头颈部肿瘤（55 例 MEC 和 63 例对照）通过荧光原位杂交技术进行了 MAML2 易位的前瞻性检测。
在诊断为 MEC 的 55 例病例中，有 41 例（75%）检测到 MAML2 易位。易位状态与组织学分级、年龄、性别、肿瘤部位或 T 分期无显著相关性。
通过荧光原位杂交技术进行 MAML2 易位的常规检测是可行的，并且有助于确认 MEC 的诊断。与组织学分级或病理分期无显著相关性表明，MAML2 易位先前报道的预后价值可能是将 MEC 误诊为其他肿瘤的人为因素。
